Two New Orleans paramedics' lives are ripped apart after they encounter a series of horrific deaths linked to a designer drug with bizarre, otherworldly effects. An agoraphobic woman living alone in New York begins spying on her new neighbors, only to witness a disturbing act of violence. After being handed the mantle of Captain America at the end of Avengers: Endgame (2019), Sam Wilson teams up with Bucky Barnes in a worldwide adventure that puts their abilities to the test.