In 2002, he was featured in Eminem’s debut film, 8 Mile, playing Papa Doc, a member of Leaders of the Free World. He was nominated for Best Supporting Actor at the 2009 Independent Spirit Awards for his role in The Hurt Locker. This is Mackie’s second ISA nomination, the first coming for his work in 2003 in Brother to Brother, where he was nominated for Best Actor. Also in 2009, Mackie portrayed rapper Tupac Shakur in the film Notorious. He appears in the 2011 Matt Damon film The Adjustment Bureau where he plays Harry Mitchell, a sympathetic member of a shadowy supernatural group that controls human destiny.